Reaction Details Report a problem with these data
Target
5'-AMP-activated protein kinase catalytic subunit alpha-2
Ligand
BDBM327916
Substrate
n/a
Meas. Tech.
Enzyme-Linked Immunosorbent Assay
EC50
<500±n/a nM
Citation
 Irving, M; Shaw, S AMPK-activating heterocyclic compounds and methods for using the same US Patent  US9663496 Publication Date 5/30/2017 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms:
AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2
Type:
Enzyme
Mol. Mass.:
62331.02
Organism:
Homo sapiens (Human)
Description:
P54646
Residue:
552
Sequence:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
  
Inhibitor
Name:
BDBM327916
Synonyms:
5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(3- methoxyphenoxy) phenyl)picolinamide | US10377742, Compound 57 | US9663496, Compound 57
Type:
Small organic molecule
Emp. Form.:
C31H29FN4O4
Mol. Mass.:
540.5848
SMILES:
COc1cccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCN(Cc4ccc(F)cc4)CC3)cc2)c1
Structure:
Search PDB for entries with ligand similarity: