Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM312186
Substrate
n/a
Meas. Tech.
Receptor Assay
Ki
1.67±0.16 nM
Citation
 McCurdy, CR; Mesangeau, C; Chin, FT; James, ML; Shen, B; Gambhir, S; Biswal, S; Behera, D Highly selective sigma receptor ligands and radioligands as probes in nociceptive processing and the pathphysiological study of memory deficits and cognitive disorders US Patent  US9724435 Publication Date 8/8/2017 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM312186
Synonyms:
US9604926, Compound CM-322 | US9724435, Compound CM-322
Type:
Small organic molecule
Emp. Form.:
C27H28F2N4O
Mol. Mass.:
462.5342
SMILES:
Fc1ccc(cc1)N1CCN(CCCCn2c3ccccc3n(-c3ccc(F)cc3)c2=O)CC1
Structure:
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