| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 72 kDa type IV collagenase |
|---|
| Ligand | BDBM12073 |
|---|
| Substrate/Competitor | MMP Fluorogenic Peptide Substrate |
|---|
| Meas. Tech. | Enzyme Assay and Determination of the Inhibition Constants. |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| Ki | 1200±n/a nM |
|---|
| Citation |  Pochetti, G; Gavuzzo, E; Campestre, C; Agamennone, M; Tortorella, P; Consalvi, V; Gallina, C; Hiller, O ; Tschesche, H; Tucker, PA; Mazza, F Structural Insight into the Stereoselective Inhibition of MMP-8 by Enantiomeric Sulfonamide Phosphonates. J Med Chem49:923-31 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| 72 kDa type IV collagenase |
|---|
| Name: | 72 kDa type IV collagenase |
|---|
| Synonyms: | 72 kDa gelatinase | 72 kDa type IV collagenase precursor | Gelatinase A | Gelatinase A (MMP-2) | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 73870.36 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08253 |
|---|
| Residue: | 660 |
|---|
| Sequence: | MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
|
|
|
|---|
| BDBM12073 |
|---|
| Name | BDBM12073 |
|---|
| Synonyms: | (S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methylpropyl]phosphonic Acid | CHEMBL382201 | [(1S)-1-{[4-(4-methoxyphenyl)benzene]sulfonamido}-2-methylpropyl]phosphonic acid | alpha-arylsulfonylamino phosphonate 1S |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H22NO6PS |
|---|
| Mol. Mass. | 399.398 |
|---|
| SMILES | COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)P(O)(O)=O |r| |
|---|
| Structure |  |
|---|
| MMP Fluorogenic Peptide Substrate |
|---|
| Name: | MMP Fluorogenic Peptide Substrate |
|---|
| Synonyms: | n/a |
|---|
| Type: | Peptide |
|---|
| Mol. Mass.: | 2468.31 |
|---|
| Organism: | n/a |
|---|
| Description: | n/a |
|---|
| Residue: | 23 |
|---|
| Sequence: | MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
|
|
|
|---|
Search and Browse
