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Target
Aurora kinase A
Ligand
BDBM12085
Substrate
CHOCKtide
Meas. Tech.
Kinase SPA Assay
IC50
>10000±n/a nM
Citation
 Pevarello, P; Fancelli, D; Vulpetti, A; Amici, R; Villa, M; Pittala, V; Vianello, P; Cameron, A; Ciomei, M; Mercurio, C; Bischoff, JR; Roletto, F; Varasi, M; Brasca, MG 3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors. Bioorg Med Chem Lett 16:1084-90 (2006) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM12085
Synonyms:
3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 3 | N-{5-acetyl-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}-4-fluorobenzamide
Type:
Small organic molecule
Emp. Form.:
C14H13FN4O2
Mol. Mass.:
288.277
SMILES:
CC(=O)N1Cc2n[nH]c(NC(=O)c3ccc(F)cc3)c2C1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
CHOCKtide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
889.06
Organism:
n/a
Description:
n/a
Residue:
7
Sequence:
LRRWSLG