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Target
Aurora kinase A
Ligand
BDBM12105
Substrate
CHOCKtide
Meas. Tech.
Kinase SPA Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
130±n/a nM
Citation
 Fancelli, D; Berta, D; Bindi, S; Cameron, A; Cappella, P; Carpinelli, P; Catana, C; Forte, B; Giordano, P; Giorgini, ML; Mantegani, S; Marsiglio, A; Meroni, M; Moll, J; Pittala, V; Roletto, F; Severino, D; Soncini, C; Storici, P; Tonani, R; Varasi, M; Vulpetti, A; Vianello, P Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition. J Med Chem 48:3080-4 (2005) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM12105
Synonyms:
1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 13 | 4-tert-butyl-N-(5-phenylacetyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide | 4-tert-butyl-N-[5-(2-phenylacetyl)-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl]benzamide | CHEMBL192575
Type:
Small organic molecule
Emp. Form.:
C24H26N4O2
Mol. Mass.:
402.4888
SMILES:
CC(C)(C)c1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
CHOCKtide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
889.06
Organism:
n/a
Description:
n/a
Residue:
7
Sequence:
LRRWSLG