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Target
MAP kinase-interacting serine/threonine-protein kinase 1
Ligand
BDBM333382
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
2.00±n/a nM
Citation
 Eis, K; Pühler, F; Zorn, L; Scholz, A; Lienau, P; Gnoth, MJ; Bömer, U; Günther, J; Fanghänel, J; Korr, D Substituted aminoimidazopyridazines US Patent  US9730929 Publication Date 8/15/2017 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 1
Synonyms:
MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
51342.85
Organism:
Homo sapiens (Human)
Description:
Q9BUB5
Residue:
465
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
  
Inhibitor
Name:
BDBM333382
Synonyms:
3-[(1R)-1-{[3-(1- Benzofuran-2- yl)imidazo[1,2-b]pyridazin- 6-yl]oxy}-2- (methylamino)ethyl]phenol | US9730929, Example 3
Type:
Small organic molecule
Emp. Form.:
C23H20N4O3
Mol. Mass.:
400.4299
SMILES:
CN(C[C@H](O)c1cccc(O)c1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r|
Structure:
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