Target
Stromelysin-1
Ligand
BDBM11331
Substrate
Substance P
Meas. Tech.
Enzyme Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
Ki
70±n/a nM
Citation
 MacPherson, LJBayburt, EKCapparelli, MPCarroll, BJGoldstein, RJustice, MRZhu, LHu, SMelton, RAFryer, LGoldberg, RLDoughty, JRSpirito, SBlancuzzi, VWilson, DO'Byrne, EMGanu, VParker, DT Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. J Med Chem 40:2525-32 (1997) [PubMed]  Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM11331
Synonyms:
2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxyacetamide | CGS 27023A Analog 22 | Hydroxamate 12 | US20230357139, Compound S
Type:
Small organic molecule
Emp. Form.:
C16H18N2O5S
Mol. Mass.:
350.39
SMILES:
COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Substance P
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
3656.51
Organism:
n/a
Description:
n/a
Residue:
32
Sequence:
ARGPRLYSPRGLNGLNPHEPHEGLYLEMETNH