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Target
Coagulation factor X
Ligand
BDBM13288
Substrate
BDBM12593
Meas. Tech.
Enzyme Assay and Determination of the Inhibition Constants.
pH
7.5±n/a
Temperature
295.15±n/a K
Ki
8±n/a nM
Citation
 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Sulfonamidopyrrolidinone factor Xa inhibitors: potency and selectivity enhancements via P-1 and P-4 optimization. J Med Chem 42:3572-87 (1999) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM13288
Synonyms:
Sulfonamidopyrrolidinone 27 | methyl 2-(4-carbamimidoyl-2-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}phenoxy)acetate | {4-(Aminoiminomethyl)-2-[3-(S)-(7-methoxynaphthalen-2-ylsulfonylamino)-2-oxopyrrolidin-1-ylmethyl]phenoxy}acetic Acid Methyl Ester
Type:
Small organic molecule
Emp. Form.:
C26H28N4O7S
Mol. Mass.:
540.588
SMILES:
COC(=O)COc1ccc(cc1CN1CC[C@H](NS(=O)(=O)c2ccc3ccc(OC)cc3c2)C1=O)C(N)=N |r|
Structure:
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Substrate
Name:
BDBM12593
Synonyms:
Chromogenic Substrate Spectrozyme FXa | MeO-CO-D-CHG-Gly-Arg-pNA.AcOH | Methoxycarbonyl-D-cyclohexylglycyl-glycyl-arginine-para-nitroanilide acetate | acetic acid; methyl N-[(R)-[({[(1S)-4-carbamimidamido-1-[(4-nitrophenyl)carbamoyl]butyl]carbamoyl}methyl)carbamoyl](cyclohexyl)methyl]carbamate
Type:
Small organic molecule
Emp. Form.:
C24H36N8O7
Mol. Mass.:
548.592
SMILES:
COC(=O)N[C@H](C1CCCCC1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure:
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