Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-gamma
Ligand
BDBM338460
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
1.000±n/a nM
Citation
Fauber, B; Gobbi, A; Rene, O; van Niel, MB; Gancia, E; Gaines, S; Ladduwahetty, T; Vesey, D; Ward, S; Winship, P Aryl sultam derivatives as RORc modulators US Patent US9751873 Publication Date 9/5/2017
More Info.:
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
Inhibitor
Name:
BDBM338460
Synonyms:
(3S,6R)-2-[[2,5-difluoro-4-[(1R,5S)- 6-(1,2,4-triazol-4-yl)-3- azabicyclo[3.1.0]hexan-3- yl]phenyl]methyl]-3-ethyl-6- phenyl-thiazinane 1,1-dioxide | US9751873, Example 147
Type:
Small organic molecule
Emp. Form.:
C26H29F2N5O2S
Mol. Mass.:
513.603
SMILES:
CC[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1cc(F)c(cc1F)N1C[C@H]2[C@@H](C1)[C@@H]2n1cnnc1 |r|