Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetACT1 (R335K)
LigandBDBM65506
Substrate/Competitorn/a
Meas. Tech.Liquid growth assay
Temperature303.15±0 K
IC50 270±0.0 nM
Citation Filipuzzi, IThomas, JRPries, VEstoppey, DSalcius, MStuder, CSchirle, MHoepfner, D Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide. ACS Chem Biol12:2264-2269 (2017) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
ACT1 (R335K)
Name:ACT1 (R335K)
Synonyms:Actin
Type:Protein
Mol. Mass.:41655.11
Organism:Baker's yeast
Description:P60010 (R335K)
Residue:375
Sequence:
MDSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQS
KRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMT
QIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDL
AGRDLTDYLMKILSERGYSFSTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSY
ELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMS
GGTTMFPGIAERMQKEITALAPSSMKVKIIAPPEKKYSVWIGGSILASLTTFQQMWISKQ
EYDESGPSIVHHKCF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM65506
NameBDBM65506
Synonyms:CHEBI:80062 | Chivosazole F | SCHEMBL1889389
TypeSmall organic molecule
Emp. Form.C41H57NO8
Mol. Mass.691.8932
SMILESCOC1CC(O)\C=C\C=C\C=C/C(C)C(OC(=O)\C=C/C=C/C=C\C(\C)=C\C(C)C(O)\C=C/C=C/c2coc(n2)C1C)C(C)C(O)CC(C)O |c:10,18,22,31,t:6,8,20,25,33|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a