Reaction Details Report a problem with these data
Target
Non-receptor tyrosine-protein kinase TYK2 [886-1187]
Ligand
BDBM127657
Substrate
n/a
Meas. Tech.
Tyk2 Inhibition Assay
IC50
>1000±n/a nM
Citation
 Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent  US9782415 Publication Date 10/10/2017 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [886-1187]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 | TYK2 | TYK2_HUMAN
Type:
n/a
Mol. Mass.:
36867.81
Organism:
Homo sapiens (Human)
Description:
aa 886-1187 P29597
Residue:
322
Sequence:
LTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM127657
Synonyms:
US10251889, Example 30 | US10758542, Example 30 | US8791123, 30 | US9782415, Example 30 | US9796724, Example 30
Type:
Small organic molecule
Emp. Form.:
C17H15F2N5O
Mol. Mass.:
343.3307
SMILES:
NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Structure:
Search PDB for entries with ligand similarity: