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TargetIntermediate conductance calcium-activated potassium channel protein 4
LigandBDBM205058
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH7.3±n/a
IC50 1700±0 nM
Commentsextracted
Citation Demnitz, JJorgensen, S Tetrazole derivatives and their use as potassium channel modulators US Patent US9556132 Publication Date 1/31/2017
More Info.:Get all data from this article,  Assay Method
 
Intermediate conductance calcium-activated potassium channel protein 4
Name:Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:IK1 | IKCa1 | KCa4 | Putative Gardos channel | SK4
Type:PROTEIN
Mol. Mass.:47723.22
Organism:Homo sapiens (Human)
Description:ChEMBL_1361891
Residue:427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM205058
NameBDBM205058
Synonyms:US9556132, 22 | process for preparing 1-(2-fluorophenyl)-5-{2-[2-(trifluoromethyl)phenyl]phenyl}-1h-1,2,3,4-tetrazole
TypeSmall organic molecule
Emp. Form.C20H12F4N4
Mol. Mass.384.3297
SMILESFc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1C(F)(F)F
Structure
n/a