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TargetMitogen-activated protein kinase 1
LigandBDBM15614
Substrate/CompetitorERKtide
Meas. Tech.Enzyme Inhibition Assay
pH7.5±n/a
Temperature303.15±n/a K
Ki 2300±n/a nM
Citation Aronov, AMBaker, CBemis, GWCao, JChen, GFord, PJGermann, UAGreen, JHale, MRJacobs, MJanetka, JWMaltais, FMartinez-Botella, GNamchuk, MNStraub, JTang, QXie, X Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors. J Med Chem50:1280-7 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | p42-MAPK
Type:Ser/Thr Protein Kinase
Mol. Mass.:41392.76
Organism:Homo sapiens (Human)
Description:P28482
Residue:360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM15614
NameBDBM15614
Synonyms:N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide | Pyrrole Carboxamide Analog 1
TypeSmall organic molecule
Emp. Form.C16H16N4O
Mol. Mass.280.3244
SMILESCN(C)C(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1ccccc1
Structure
ERKtide
Name:ERKtide
Synonyms:n/a
Type:Peptide
Mol. Mass.:1314.49
Organism:n/a
Description:n/a
Residue:13
Sequence:
ATGPLSPGPFGRR