| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-Dependent Kinase 9 (CDK9) |
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| Ligand | BDBM167604 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LANCE ULight TR-FRET Kinase Assay |
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| IC50 | 34.0±n/a nM |
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| Citation |  Tong, Y; Bruncko, M; Clark, RF; Curtin, M; Florjancic, AS; Frey, RR; Gong, J; Hansen, TM; Ji, Z; Lai, C; Mastracchio, A; Michaelides, M; Miyashiro, J; Risi, RM; Song, X; Tao, Z; Woods, KW; Zhu, G; Penning, T; Souers, A; Goswami, R; Iguturi, OR; Dabbeeru, MB Pyrrolo [2,3-B] pyridine CDK9 kinase inhibitors US Patent US9796708 Publication Date 10/24/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cyclin-Dependent Kinase 9 (CDK9) |
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| Name: | Cyclin-Dependent Kinase 9 (CDK9) |
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| Synonyms: | CDK9/ Cyclin-T1 | CDK9/CycT1 | CDK9/Cyclin T | CDK9/Cyclin T1 | Cyclin T1/dependent kinase 9 |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-T1 |
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| Synonyms: | CycT | CycT1 | Cyclin T | Cyclin T1 | Cyclin-T |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 80712.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 726 |
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| Sequence: | MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTIN
TAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPD
TRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATN
SLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHE
FLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLM
SMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV
DHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAY
AAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEI
KMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNK
RPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSL
NFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDT
VNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPP
LPPLPK
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|
|
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| Component 2 |
| Name: | CDK4/CDK9 |
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| Synonyms: | C-2K | CDC2L4 | CDK9 | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 42789.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 372 |
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| Sequence: | MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP
ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK
FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS
QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP
ATTNQTEFERVF
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| BDBM167604 |
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| Name | BDBM167604 |
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| Synonyms: | US9073922, 89 | US9796708, Example 89 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31N5O |
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| Mol. Mass. | 405.5358 |
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| SMILES | CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCC2CCOCC2)n1 |
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| Structure | 
|
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| n/a |
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