Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM16315
Substrate
BDBM16443
Meas. Tech.
In Vitro Aldose Reductase Inhibition Assay
pH
7±n/a
Temperature
297.15±n/a K
IC50
0.84±0.04 nM
Citation
 Mylari, BLArmento, SJBeebe, DAConn, ELCoutcher, JBDina, MSO'Gorman, MTLinhares, MCMartin, WHOates, PJTess, DAWithbroe, GJZembrowski, WJ A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one. J Med Chem 46:2283-6 (2003) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM16315
Synonyms:
6-[(5-chloro-3-methyl-1-benzofuran-2-)sulfonyl]-2,3-dihydropyridazin-3-one | 6-[(5-chloro-3-methyl-1-benzofuran-2-yl)sulfonyl]pyridazin-3(2H)-one | 62P | CHEMBL240725 | CP-744809 | Heterocyclic Sulfonylpyridazinone, 19m | Pyridazinone | benzofuran, 24
Type:
Small organic molecule
Emp. Form.:
C13H9ClN2O4S
Mol. Mass.:
324.74
SMILES:
Cc1c(oc2ccc(Cl)cc12)S(=O)(=O)c1ccc(=O)[nH]n1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM16443
Synonyms:
(2R)-2,3-dihydroxypropanal | D-glyceraldehyde | Triose
Type:
Small organic molecule
Emp. Form.:
C3H6O3
Mol. Mass.:
90.0779
SMILES:
OC[C@@H](O)C=O
Structure:
Search PDB for entries with ligand similarity: