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Target
Proteinase-activated receptor 4
Ligand
BDBM176277
Substrate
n/a
Meas. Tech.
PAR4 FLIPR assay
Temperature
298.15±n/a K
EC50
0.530±n/a nM
Comments
extracted
Citation
 Banville, J; Remillard, R; Ruediger, EH; Deon, DH; Gagnon, M; Dube, L; Guy, J; Priestley, ES; Posy, SL; Maxwell, BD; Wong, PC; Lawrence, RM; Miller, MM Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent  US10047103 Publication Date 8/14/2018 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM176277
Synonyms:
US10047103, 310 | US9688695, 310
Type:
Small organic molecule
Emp. Form.:
C29H27N5O5S2
Mol. Mass.:
589.685
SMILES:
COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N(C)C(C)C)cc(OC)cc2o1
Structure:
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