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Target
Baculoviral IAP repeat-containing protein 2 [266-354]
Ligand
BDBM17345
Substrate
BDBM17342
Meas. Tech.
Fluorescence Polarization Affinity Measurements.
pH
7.2±n/a
Temperature
295.15±n/a K
Ki
50±n/a nM
Citation
 Zobel, K; Wang, L; Varfolomeev, E; Franklin, MC; Elliott, LO; Wallweber, HJ; Okawa, DC; Flygare, JA; Vucic, D; Fairbrother, WJ; Deshayes, K Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol 1:525-33 (2006) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 2 [266-354]
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | Chimeric protein of inhibitor of apoptosis protein 2-baculovirus IAP repeat 3 (BIR3) | MIHB | RNF48 | cIAP1-BIR3 | cIAP1-BIR3/XIAP-BIR3 chimeric protein | cIAP1XBIR3
Type:
Chimeric Protein
Mol. Mass.:
10496.31
Organism:
Homo sapiens (Human)
Description:
Q13490[266-354]
Residue:
89
Sequence:
MQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPH
  
Inhibitor
Name:
BDBM17345
Synonyms:
(3R,6S,9aR)-2,2-dimethyl-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-6-[(2S)-2-(methylamino)propanamido]-5-oxo-octahydroazepino[2,1-b][1,3]thiazole-3-carboxamide | peptide isostere, 8
Type:
Small organic molecule
Emp. Form.:
C25H34N6O3S
Mol. Mass.:
498.641
SMILES:
[H][C@@]12CCC[C@H](NC(=O)[C@H](C)NC)C(=O)N1[C@H](C(=O)Nc1cc(C)nn1-c1ccccc1)C(C)(C)S2 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM17342
Synonyms:
5-carboxyflourescein(5-FAM)-conjugated AVPFFAKK | AVP-diPhe-FAM
Type:
Fluorescent dye-conjugated peptide
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: