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TargettRNA synthetase (TyrRS)
LigandBDBM18131
Substrate/CompetitorBDBM18129
Meas. Tech.Tyrosyl tRNA Synthetase Inhibition Assay
pH7.9±n/a
Temperature310.15±n/a K
IC50 0.2±n/a nM
Citation Qiu, XJanson, CASmith, WWGreen, SMMcDevitt, PJohanson, KCarter, PHibbs, MLewis, CChalker, AFosberry, ALalonde, JBerge, JBrown, PHouge-Frydrych, CSJarvest, RL Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors. Protein Sci10:2008-16 (2001) [PubMed]  Article
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tRNA synthetase (TyrRS)
Name:tRNA synthetase (TyrRS)
Synonyms:Tyrosine--tRNA ligase
Type:Enzyme
Mol. Mass.:47586.43
Organism:Staphylococcus aureus
Description:n/a
Residue:420
Sequence:
MTNVLIEDLKWRGLIYQQTDEQGIEDLLNKEQVTLYCGADPTADSLHIGHLLPFLTLRRF
QEHGHRPIVLIGGGTGMIGDPSGKSEERVLQTEEQVDKNIEGISKQMHNIFEFGTDHGAV
LVNNRDWLGQISLISFLRDYGKHVGVNYMLGKDSIQSRLEHGISYTEFTYTILQAIDFGH
LNRELNCKIQVGGSDQWGNITSGIELMRRMYGQTDAYGLTIPLVTKSDGKKFGKSESGAV
WLDAEKTSPYEFYQFWINQSDEDVIKFLKYFTFLGKEEIDRLEQSKNEAPHLREAQKTLA
EEVTKFIHGEDALNDAIRISQALFSGDLKSLSAKELKDGFKDVPQVTLSNDTTNIVEVLI
ETGISPSKRQAREDVNNGAIYINGERQQDVNYALAPEDKIDGEFTIIRRGKKKYFMVNYQ
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BDBM18131
NameBDBM18131
Synonyms:SB-243545 | butyl (2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-2-[(2S,3S,4S,5S)-1,3,4,5-tetrahydroxy-4-(hydroxymethyl)piperidin-2-yl]acetate
TypeSmall organic molecule
Emp. Form.C21H33N3O9
Mol. Mass.471.5014
SMILES[H][C@]1([C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)OCCCC)[C@H](O)[C@](O)(CO)[C@@H](O)CN1O |r|
Structure
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BDBM18129
NameBDBM18129
Synonyms:(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L-[U-14C]Tyr | Tyrosine
TypeAmino Acid
Emp. Form.C9H11NO3
Mol. Mass.181.1885
SMILESN[C@@H](Cc1ccc(O)cc1)C(O)=O
Structure
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