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TargetCathepsin D
LigandBDBM228421
Substrate/Competitorn/a
Meas. Tech.In Vitro Enzymatic
pH3.5±n/a
IC50 33700±n/a nM
Commentsextracted
Citation Lewis, RTAllen, JRCheng, YChoquette, DEpstein, OGuzman-Perez, AHarrington, PEHua, ZHungate, RWHuman, JBJudd, TLiu, QLopez, PMinatti, AEOlivieri, PRomero, KRumfelt, SRzasa, RMSchenkel, LStellwagen, JWhite, RXue, QZheng, XMZhong, W Amino-dihydrothiazine and amino-dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use US Patent US9556135 Publication Date 1/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin D
Name:Cathepsin D
Synonyms:Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:Enzyme
Mol. Mass.:44551.72
Organism:Homo sapiens (Human)
Description:Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM228421
NameBDBM228421
Synonyms:US9556135, 79
TypeSmall organic molecule
Emp. Form.C23H23FN2O2S2
Mol. Mass.442.569
SMILESCC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(Sc2cccc3ccccc23)ccc1F |r,c:4|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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