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TargetGlucocerebrosidase (Acid beta-Glucosidase)
LigandBDBM18363
Substrate/CompetitorBDBM18352
Meas. Tech.In Vitro Enzyme Inhibition
pH5.5±n/a
Temperature310.15±n/a K
Ki 280±n/a nM
IC50 500±n/a nM
CommentsCompetitive inhibition.
Citation Yu, LIkeda, KKato, AAdachi, IGodin, GCompain, PMartin, OAsano, N Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease. Bioorg Med Chem14:7736-44 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Glucocerebrosidase (Acid beta-Glucosidase)
Name:Beta-glucocerebrosidase
Synonyms:β-glucocerebrosidase (GCase) | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase). | Imiglucerase
Type:Enzyme
Mol. Mass.:59724.64
Organism:Homo sapiens (human)
Description:The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
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BDBM18363
NameBDBM18363
Synonyms:(2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-octylpiperidine-3,4,5-triol | CO-DNJ | alpha-1-C-Octyl-DNJ
TypeSmall organic molecule
Emp. Form.C14H29NO4
Mol. Mass.275.3844
SMILESCCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Structure
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BDBM18352
NameBDBM18363
Synonyms:(2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-octylpiperidine-3,4,5-triol | CO-DNJ | alpha-1-C-Octyl-DNJ
TypeSmall organic molecule
Emp. Form.C14H29NO4
Mol. Mass.275.3844
SMILESCCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Structure
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