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TargetBIR3
LigandBDBM242614
Substrate/Competitorn/a
Meas. Tech.TR-FRET Assay for BIR2 and BIR3
pH7.5±n/a
Temperature298.15±n/a K
IC50 31930±n/a nM
Commentsextracted
Citation Chen, SDonnell, AFKester, RFLe, KLou, YMichoud, CRemiszewski, SRupert, KCWeisel, M Tetrahydro-benzodiazepinones US Patent US10053431 Publication Date 8/21/2018  Article
More Info.:Get all data from this article,  Assay Method
 
BIR3
Name:BIR3
Synonyms:BIR3 domain | XIAP Bir3 | amino acids 241-356 of XIAP
Type:Enzyme Catalytic Domain
Mol. Mass.:14548.06
Organism:Homo sapiens (Human)
Description:n/a
Residue:125
Sequence:
MRHHHHHHRSDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYA
LGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEEC
LVRTT
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BDBM242614
NameBDBM242614
Synonyms:(S)—N—((S)-5-(4-acetylbenzoyl)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-aminopropanamide hydrochloride | US10053431, 39
TypeSmall organic molecule
Emp. Form.C33H31BrN4O5
Mol. Mass.643.527
SMILESCOc1ccc2cc(Br)ccc2c1CN1c2ccccc2N(C[C@H](NC(=O)[C@H](C)N)C1=O)C(=O)c1ccc(cc1)C(C)=O |r|
Structure
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n/a