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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM19188
Substrate
BDBM10990
Meas. Tech.
MAO A Activity Measurement
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
15700±2000 nM
Citation
 Binda, C; Wang, J; Pisani, L; Caccia, C; Carotti, A; Salvati, P; Edmondson, DE; Mattevi, A Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs. J Med Chem 50:5848-5852 (2007) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM19188
Synonyms:
7-(3-chlorobenzyloxy)-4-(methylamino)methyl-coumarin, 2 | 7-[(3-chlorophenyl)methoxy]-4-[(methylamino)methyl]-2H-chromen-2-one | C18 | CHEMBL593763
Type:
Small organic molecule
Emp. Form.:
C18H16ClNO3
Mol. Mass.:
329.778
SMILES:
CNCc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Structure:
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Substrate
Name:
BDBM10990
Synonyms:
3-amino-1-(2-aminophenyl)propan-1-one | Diaminopropiophenone | Kynuramine
Type:
Small organic molecule
Emp. Form.:
C9H12N2O
Mol. Mass.:
164.2044
SMILES:
NCCC(=O)c1ccccc1N
Structure:
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