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Reaction Details
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TargetCathepsin L1
LigandBDBM19736
Substrate/CompetitorBDBM19485
Meas. Tech.Enzyme Inhibition Assay
pH5.5±n/a
Temperature295.15±n/a K
IC50 0.34±n/a nM
Km850±n/a nM
Citation Altmann, EAichholz, RBetschart, CBuhl, TGreen, JIrie, OTeno, NLattmann, RTintelnot-Blomley, MMissbach, M 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem50:591-4 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Cathepsin L1
Name:Cathepsin (L and K)
Synonyms:Cathepsin (L and K) | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM19736
NameBDBM19736
Synonyms:2-Cyano-pyrimidine, 17a | 2-cyano-4-[(2,2-dimethylpropyl)amino]-N-[2-(4-methoxyphenyl)ethyl]pyrimidine-5-carboxamide
TypeSmall organic molecule
Emp. Form.C20H25N5O2
Mol. Mass.367.4448
SMILESCOc1ccc(CCNC(=O)c2cnc(nc2NCC(C)(C)C)C#N)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
BDBM19485
NameBDBM19485
Synonyms:Cbz-Phe-Arg-AMC | Fluorogenic substrate | Z-Phe-Arg-AMC.HCl
Typen/a
Emp. Form.n/a
Mol. Mass.n/a
SMILESn/a
Structure