Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM143779
Substrate
n/a
Meas. Tech.
Receptor Radioligand Binding Assay
Ki
340±n/a nM
Citation
 Gelin, CF; Lebold, TP; Shireman, BT Substituted 2-azabicycles and their use as orexin receptor modulators US Patent  US9845333 Publication Date 12/19/2017 
Target
Name:
Orexin receptor type 2
Synonyms:
Hcrtr2 | Hypocretin receptor type 2 | OX2R_RAT | Orexin receptor 2 | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Ox-2-R | Ox2-R | Ox2R
Type:
Protein
Mol. Mass.:
52508.46
Organism:
Rattus norvegicus (Rat)
Description:
P56719
Residue:
460
Sequence:
MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
  
Inhibitor
Name:
BDBM143779
Synonyms:
US10183953, Example 40 | US8969352, 40 | US9611277, Example 40 | US9845333, 40
Type:
Small organic molecule
Emp. Form.:
C24H21F3N4O3
Mol. Mass.:
470.4437
SMILES:
COc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:21:20:16.17:33,14:16:20.19:33|
Structure:
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