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TargetCathepsin S
LigandBDBM19856
Substrate/CompetitorBDBM19490
Meas. Tech.Enzyme Inhibition Assay and Whole Cell Enzyme Occupancy Assay
pH6.5±n/a
Temperature295.15±n/a K
IC50 20000±7000 nM
EC50 1340±400 nM
Citation Falgueyret, JPDesmarais, SOballa, RBlack, WCCromlish, WKhougaz, KLamontagne, SMassé, FRiendeau, DToulmond, SPercival, MD Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. J Med Chem48:7535-43 (2005) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cathepsin S
Name:Cathepsin S
Synonyms:CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:Protein
Mol. Mass.:37507.38
Organism:Homo sapiens (Human)
Description:P25774
Residue:331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
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  Blast E-value cutoff:
BDBM19856
NameBDBM19856
Synonyms:(2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1-yl)phenyl]phenyl}pentanamide | CHEMBL184514 | JMC463709 (R)-2 | piperazine-containing compound, 11
TypeSmall organic molecule
Emp. Form.C24H30N4O
Mol. Mass.390.5212
SMILESCC(C)C[C@@H](C(=O)NCC#N)c1cccc(c1)-c1ccc(cc1)N1CCNCC1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
BDBM19490
NameBDBM19490
Synonyms:Cbz-Val-Val-Arg-AMC | Fluorogenic substrate | Z-Val-Val-Arg-AMC
Typen/a
Emp. Form.n/a
Mol. Mass.n/a
SMILESn/a
Structure