Target

Ligand

Substrate

Meas. Tech.

Enzyme Inhibition Assay

Citation

 Robichaud, J; Oballa, R; Prasit, P; Falgueyret, JP; Percival, MD; Wesolowski, G; Rodan, SB; Kimmel, D; Johnson, C; Bryant, C; Venkatraman, S; Setti, E; Mendonca, R; Palmer, JT A novel class of nonpeptidic biaryl inhibitors of human cathepsin K. J Med Chem 46:3709-27 (2003) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

Procathepsin L

Synonyms:

CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein

Type:

Enzyme

Mol. Mass.:

37557.19

Organism:

Homo sapiens (Human)

Description:

Purchased from Calbiochem (San Diego, CA).

Residue:

333

Sequence:

MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM19881

Synonyms:

N-(cyanomethyl)-4-methyl-2-{3-[3-(piperazin-1-yl)phenyl]phenyl}pentanamide | Nonpeptidic Biaryl Nitrile Compound, 43

Type:

Small organic molecule

Emp. Form.:

C24H30N4O

Mol. Mass.:

390.5212

SMILES:

CC(C)CC(C(=O)NCC#N)c1cccc(c1)-c1cccc(c1)N1CCNCC1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

BDBM19480

Synonyms:

Cbz-Leu-Arg-AMC | Fluorogenic substrate | Z-Leu-Arg-AMC

Type:

n/a

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: