Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM19893
Substrate
BDBM19480
Meas. Tech.
Enzyme Inhibition Assay
IC50
9546±n/a nM
Citation
Robichaud, J; Oballa, R; Prasit, P; Falgueyret, JP; Percival, MD; Wesolowski, G; Rodan, SB; Kimmel, D; Johnson, C; Bryant, C; Venkatraman, S; Setti, E; Mendonca, R; Palmer, JT A novel class of nonpeptidic biaryl inhibitors of human cathepsin K. J Med Chem 46:3709-27 (2003) [PubMed] Article
More Info.:
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Inhibitor
Name:
BDBM19893
Synonyms:
(2R)-N-(cyanomethyl)-2-(3-{4-[4-(2-hydroxy-2-methylpropyl)piperazin-1-yl]phenyl}phenyl)-4-methylpentanamide | Nonpeptidic Biaryl Nitrile Compound, 13
Type:
Small organic molecule
Emp. Form.:
C28H38N4O2
Mol. Mass.:
462.6269
SMILES:
CC(C)C[C@@H](C(=O)NCC#N)c1cccc(c1)-c1ccc(cc1)N1CCN(CC(C)(C)O)CC1 |r|