Reaction Details Report a problem with these data
Target
P2X purinoceptor 3
Ligand
BDBM244300
Substrate
n/a
Meas. Tech.
Receptor Inhibition Assay
pH
7.5±n/a
IC50
22.0±n/a nM
Comments
extracted
Citation
 Kai, H; Tanaka, S; Hiramatsu, Y; Nozu, A; Nakamura, K Heterocyclic ring and carbocyclic derivative US Patent  US9550763 Publication Date 1/24/2017 
Target
Name:
P2X purinoceptor 3
Synonyms:
ATP receptor | Glucocorticoid receptor | P2RX3 | P2RX3_HUMAN | P2X purinoceptor 3 | P2X purinoceptor 3 (P2RX3) | P2X purinoceptor 3 (P2X3) | P2X3 | P2X3 purinoceptor | Purinergic receptor | p2x3 + hsa
Type:
Protein
Mol. Mass.:
44292.02
Organism:
Homo sapiens (Human)
Description:
P56373
Residue:
397
Sequence:
MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
  
Inhibitor
Name:
BDBM244300
Synonyms:
US9550763, Compound I-048
Type:
Small organic molecule
Emp. Form.:
C27H28ClN5O3
Mol. Mass.:
505.996
SMILES:
CCc1oc2ccc(cc2c1C)\N=c1/[nH]cc(\C=N\N2CCOCC2)c(=O)n1Cc1ccc(Cl)cc1 |w:16.18|
Structure:
Search PDB for entries with ligand similarity: