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TargetLiver X Receptor beta (LXR-beta)
LigandBDBM20025
Substrate/CompetitorBDBM19993
Meas. Tech.LXR Binding Assay
IC50 5.4±n/a nM
EC50 795±n/a nM
Citation Hu, BJetter, JKaufman, DSinghaus, RBernotas, RUnwalla, RQuinet, ESavio, DHalpern, ABasso, MKeith, JClerin, VChen, LLiu, QYFeingold, IHuselton, CAzam, FGoos-Nilsson, AWilhelmsson, ANambi, PWrobel, J Further modification on phenyl acetic acid based quinolines as liver X receptor modulators. Bioorg Med Chem15:3321-33 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Liver X Receptor beta (LXR-beta)
Name:Liver X Receptor beta (LXR-beta)
Synonyms:Nuclear orphan receptor LXR-beta | Nuclear receptor NER | Nuclear receptor subfamily 1 group H member 2 | Oxysterols receptor LXR-beta | Ubiquitously-expressed nuclear receptor
Type:Receptor
Mol. Mass.:34695.50
Organism:Homo sapiens (human)
Description:LXR beta ligand binding domain (amino acid residues 154-461) with an N-terminal biotinylation tag expressed in E.coli, was used for the binding assays.
Residue:308
Sequence:
MREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSG
EGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTE
LAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDF
TYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVE
ALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLL
SEIWDVHE
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BDBM20025
BDBM19993
NameBDBM20025
Synonyms:2-{4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}ethan-1-ol | ethanol analogue, 37
TypeSmall organic molecule
Emp. Form.C32H25F3N2O2
Mol. Mass.526.5483
SMILESOCCc1ccc(CNc2cccc(c2)-c2c(cnc3c(cccc23)C(F)(F)F)C(=O)c2ccccc2)cc1
Structure
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