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TargetLiver X Receptor beta (LXR-beta)
LigandBDBM20008
Substrate/CompetitorBDBM19993
Meas. Tech.LXR Binding Assay and hLXR beta Reporter Assay
pH7.4±n/a
Temperature277.15±n/a K
IC50 33.8±n/a nM
EC50 450±n/a nM
CommentsEfficacy=89% in transfected hLXRbeta reporter cell line assay.
Citation Hu, BJetter, JKaufman, DSinghaus, RBernotas, RUnwalla, RQuinet, ESavio, DHalpern, ABasso, MKeith, JClerin, VChen, LLiu, QYFeingold, IHuselton, CAzam, FGoos-Nilsson, AWilhelmsson, ANambi, PWrobel, J Further modification on phenyl acetic acid based quinolines as liver X receptor modulators. Bioorg Med Chem15:3321-33 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Liver X Receptor beta (LXR-beta)
Name:Liver X Receptor beta (LXR-beta)
Synonyms:Nuclear orphan receptor LXR-beta | Nuclear receptor NER | Nuclear receptor subfamily 1 group H member 2 | Oxysterols receptor LXR-beta | Ubiquitously-expressed nuclear receptor
Type:Receptor
Mol. Mass.:34695.50
Organism:Homo sapiens (human)
Description:LXR beta ligand binding domain (amino acid residues 154-461) with an N-terminal biotinylation tag expressed in E.coli, was used for the binding assays.
Residue:308
Sequence:
MREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSG
EGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTE
LAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDF
TYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVE
ALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLL
SEIWDVHE
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BDBM20008
NameBDBM20008
Synonyms:2-{4-[({3-[3-cyano-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetic acid | phenyl acetic acid based quinoline, 20
TypeSmall organic molecule
Emp. Form.C26H18F3N3O2
Mol. Mass.461.4352
SMILESOC(=O)Cc1ccc(CNc2cccc(c2)-c2c(cnc3c(cccc23)C(F)(F)F)C#N)cc1
Structure
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BDBM19993
NameBDBM19993
Synonyms:CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide | T 0901317 | T0901317 | TO-901317 | [3H]T0901317
TypeSmall organic molecule
Emp. Form.C17H12F9NO3S
Mol. Mass.481.333
SMILESOC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
Structure
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