Reaction Details Report a problem with these data
Target
Papain
Ligand
BDBM20088
Substrate
BDBM20081
Meas. Tech.
Papain Inhibition Assay
pH
6.5±n/a
Temperature
298.15±n/a K
Ki
26000±1000 nM
Km
965000±244000 nM
Citation
Löser, R; Schilling, K; Dimmig, E; Gütschow, M Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem 48:7688-707 (2005) [PubMed] Article
Target
Name:
Papain
Synonyms:
Allergen=Car p 1 | PAPA1_CARPA | PPI | Papaya proteinase I
Type:
Enzyme
Mol. Mass.:
38923.01
Organism:
Carica papaya
Description:
Papain was purchased from Sigma, Germany.
Residue:
345
Sequence:
MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYKNIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTELSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNEYSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYGPNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
Inhibitor
Name:
BDBM20088
Synonyms:
dipeptide-derived nitrile, 9 | tert-butyl N-[(1S,2R)-1-[(cyanomethyl)carbamoyl]-2-methylbutyl]carbamate
Type:
Small organic molecule
Emp. Form.:
C13H23N3O3
Mol. Mass.:
269.34
SMILES:
CC[C@@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)NCC#N |r|