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Reaction Details
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TargetPapain
LigandBDBM20096
Substrate/CompetitorBDBM20081
Meas. Tech.Papain Inhibition Assay
pH6.5±n/a
Temperature298.15±n/a K
Ki 360±10 nM
Km965000±244000 nM
Citation Löser, RSchilling, KDimmig, EGütschow, M Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem48:7688-707 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Papain
Name:Papain
Synonyms:Allergen=Car p 1 | PPI | Papaya proteinase I
Type:Enzyme
Mol. Mass.:38923.01
Organism:Carica papaya
Description:Papain was purchased from Sigma, Germany.
Residue:345
Sequence:
MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYK
NIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTE
LSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNE
YSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKT
DGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYG
PNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM20096
NameBDBM20096
Synonyms:CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-phenylethyl]carbamate | dipeptide-derived nitrile, 17
TypeSmall organic molecule
Emp. Form.C19H19N3O3
Mol. Mass.337.3725
SMILESO=C(N[C@@H](Cc1ccccc1)C(=O)NCC#N)OCc1ccccc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
BDBM20081
NameBDBM20081
Synonyms:Z-Phe-Arg-NH-4-nitrophenyl | Z-Phe-Arg-NHNp
Typen/a
Emp. Form.n/a
Mol. Mass.n/a
SMILESn/a
Structure