Target

Ligand

Substrate

Meas. Tech.

Papain Inhibition Assay

Ki

1200±n/a nM

Citation

 Löser, R; Schilling, K; Dimmig, E; Gütschow, M Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem 48:7688-707 (2005) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

Procathepsin L

Synonyms:

CATL1_BOVIN | CTSL | CTSL1 | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain

Type:

Enzyme

Mol. Mass.:

37349.52

Organism:

Bos taurus (bovine)

Description:

Bovine liver cathepsin L was purchased from Calbiochem.

Residue:

334

Sequence:

MNPSFFLTVLCLGVASAAPKLDPNLDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQEYSEGKHGFRMAMNAFGDMTNEEFRQVMNGFQNQKHKKGKLFHEPLLVDVPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIPQREKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM20087

Synonyms:

dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-3-methylbutyl]carbamate

Type:

Small organic molecule

Emp. Form.:

C13H23N3O3

Mol. Mass.:

269.34

SMILES:

CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC#N |r|

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

BDBM20128

Synonyms:

Z-Phe-Arg-NH-4-methylcoumarin-7-yl | Z-Phe-Arg-NHMec

Type:

n/a

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: