Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM20088
Substrate
BDBM20130
Meas. Tech.
Papain Inhibition Assay
Ki
5800±n/a nM
Citation
 Löser, R; Schilling, K; Dimmig, E; Gütschow, M Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem 48:7688-707 (2005) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM20088
Synonyms:
dipeptide-derived nitrile, 9 | tert-butyl N-[(1S,2R)-1-[(cyanomethyl)carbamoyl]-2-methylbutyl]carbamate
Type:
Small organic molecule
Emp. Form.:
C13H23N3O3
Mol. Mass.:
269.34
SMILES:
CC[C@@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)NCC#N |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM20130
Synonyms:
Z-Leu-Arg-NH-4-methylcoumarin-7-yl | Z-Leu-Arg-NHMec
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: