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Target
Proteinase-activated receptor 4
Ligand
BDBM364754
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
333±n/a nM
Citation
 Lawrence, RM; Miller, MM; Seiffert, DA; Posy, SL; Wong, PC; Banville, J; Ruediger, EH; Deon, DH; Martel, A; Tremblay, F; Guy, J; Lavallée, J; Gagnon, M Imidazothiadiazole derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent  US9862730 Publication Date 1/9/2018 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM364754
Synonyms:
(R)- and (S)-6-(4,6-Dichlorobenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole | US9862730, Example 213A | US9862730, Example 213B
Type:
Small organic molecule
Emp. Form.:
C14H8Cl2FN3OS
Mol. Mass.:
356.202
SMILES:
C[C@H](F)c1nn2cc(nc2s1)-c1cc2c(Cl)cc(Cl)cc2o1 |r|
Structure:
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