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Target
P2X purinoceptor 7
Ligand
BDBM246968
Substrate
n/a
Meas. Tech.
P2X7 Radioligand Binding
Ki
10.5±n/a nM
Citation
 Ameriks, MK; Rech, JC; Savall, BM; Wall, JL Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators US Patent  US10053463 Publication Date 8/21/2018 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM246968
Synonyms:
(S)-3-(2-chloro-3-(trifluoromethyl)phenyl)-5-methyl-8-(4-methylpyridin-2-yl)-5,6-dihydrobis([1,2,4]triazolo)[4,3-a:3′,4′-c]pyrazine | US10053463, 125
Type:
Small organic molecule
Emp. Form.:
C20H15ClF3N7
Mol. Mass.:
445.828
SMILES:
C[C@H]1Cn2c(nnc2-c2cc(C)ccn2)-c2nnc(-c3cccc(c3Cl)C(F)(F)F)n12 |r|
Structure:
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