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Target
Mitogen-activated protein kinase 14
Ligand
BDBM20654
Substrate
myelin basic protein
Meas. Tech.
In Vitro Enzyme Inhibition Assay and Cell-based TNFalpha Biosynthesis Inhibition Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
8.0±n/a nM
EC50
43±n/a nM
Citation
 Hynes, J; Dyckman, AJ; Lin, S; Wrobleski, ST; Wu, H; Gillooly, KM; Kanner, SB; Lonial, H; Loo, D; McIntyre, KW; Pitt, S; Shen, DR; Shuster, DJ; Yang, X; Zhang, R; Behnia, K; Zhang, H; Marathe, PH; Doweyko, AM; Tokarski, JS; Sack, JS; Pokross, M; Kiefer, SE; Newitt, JA; Barrish, JC; Dodd, J; Schieven, GL; Leftheris, K Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors. J Med Chem 51:4-16 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM20654
Synonyms:
N-cyclopentyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[1,2-a][1,2,4]triazine-6-carboxamide | pyrrolo[2,1-f][1,2,4]triazine analogue, 11g
Type:
Small organic molecule
Emp. Form.:
C22H26N6O3
Mol. Mass.:
422.4802
SMILES:
CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)NC4CCCC4)c(C)c23)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
myelin basic protein
Synonyms:
myelin A1 protein
Type:
Other Protein Type
Mol. Mass.:
4541.90
Organism:
Oryctolagus cuniculus (rabbit)
Description:
n/a
Residue:
42
Sequence:
FGSDRGAPKRGSGKDHAARTTHYGSLPQKSGHRPQDENPVVH