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TargetDiacylglycerol O-acyltransferase 1 (DGAT1)
LigandBDBM20726
Substrate/CompetitorBDBM20717
Meas. Tech.In Vitro FlashPlate Assay
pH7.5±n/a
Temperature295.15±n/a K
IC50 9±n/a nM
Citation Zhao, GSouers, AJVoorbach, MFalls, HDDroz, BBrodjian, SLau, YYIyengar, RRGao, JJudd, ASWagaw, SHRavn, MMEngstrom, KMLynch, JKMulhern, MMFreeman, JDayton, BDWang, XGrihalde, NFry, DBeno, DWMarsh, KCSu, ZDiaz, GJCollins, CASham, HReilly, RMBrune, MEKym, PR Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J Med Chem51:380-3 (2008) [PubMed]  Article
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Diacylglycerol O-acyltransferase 1 (DGAT1)
Name:Diacylglycerol O-acyltransferase 1
Synonyms:ACAT-related gene product 1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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BDBM20726
NameBDBM20726
Synonyms:(1R,2R)-2-({4-[4-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]phenyl}carbonyl)cyclopentane-1-carboxylic acid | Urea-based Analogue, 4j
TypeSmall organic molecule
Emp. Form.C27H23F3N2O4
Mol. Mass.496.4777
SMILESOC(=O)[C@@H]1CCC[C@H]1C(=O)c1ccc(cc1)-c1ccc(NC(=O)Nc2ccc(cc2)C(F)(F)F)cc1 |r|
Structure
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BDBM20717
NameBDBM20717
Synonyms:(1-decanoyloxy-3-hydroxypropan-2-yl) decanoate | 1,2-didecanoyl-sn-glycerol | 1-(decanoyloxy)-3-hydroxypropan-2-yl decanoate | didecanoyl glycerol
Typen/a
Emp. Form.C23H44O5
Mol. Mass.400.5925
SMILESCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCC
Structure
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