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Target
VIM-1 protein
Ligand
BDBM367939
Substrate
n/a
Meas. Tech.
Enzyme Activity
IC50
0.477±n/a nM
Citation
 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Metallo-beta-lactamase inhibitors US Patent  US10227331 Publication Date 3/12/2019 
Target
Name:
VIM-1 protein
Synonyms:
Beta-lactamase VIM-1 | Class B carbapenemase VIM-1 | Metallo-beta-lactamase VIM-1 | Metallobeta-lactamase | VIM-1 | VIM-1 metallo-beta lactamase | VIM-1 metallo-beta-lactamase | VIM-1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28014.53
Organism:
Pseudomonas aeruginosa
Description:
n/a
Residue:
266
Sequence:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
  
Inhibitor
Name:
BDBM367939
Synonyms:
3-((4-(3-methyl-1H- indazol-5-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl)azetidin- 1-ium 2,2,2- trifluoroacetate | US10227331, Example 126
Type:
Small organic molecule
Emp. Form.:
C18H18N8O4S2
Mol. Mass.:
474.517
SMILES:
Cc1n[nH]c2ccc(cc12)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)C1CNC1
Structure:
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