Target
Thymidine kinase
Ligand
BDBM21877
Substrate
BDBM21867
Meas. Tech.
Thymidine Kinase Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
3600±n/a nM
Km
1000±n/a nM
Citation
 Manikowski, AVerri, ALossani, AGebhardt, BMGambino, JFocher, FSpadari, SWright, GE Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo. J Med Chem 48:3919-29 (2005) [PubMed]  Article 
Target
Name:
Thymidine kinase
Synonyms:
TK
Type:
Transferase
Mol. Mass.:
40915.49
Organism:
Human herpesvirus 1
Description:
O72346
Residue:
376
Sequence:
MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGEAN
  
Inhibitor
Name:
BDBM21877
Synonyms:
2,9-disubstituted 6-oxopurine, 12a | 9-[4-(dimethylamino)butyl]-2-(phenylamino)-6,9-dihydro-3H-purin-6-one dihydrochloride | CHEMBL441732
Type:
Small organic molecule
Emp. Form.:
C17H22N6O
Mol. Mass.:
326.3962
SMILES:
CN(C)CCCCn1cnc2c1nc(Nc1ccccc1)[nH]c2=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM21867
Synonyms:
[3H-methyl]TdR | [3H]thymidine
Type:
radiolabeled ligand
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: