| Reaction Details |
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| Target | Indoleamine 2,3-Dioxygenase |
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| Ligand | Exiguamine A |
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| Substrate/Competitor | L-tryptophan |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 6.5±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | 41±3 nM |
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| Citation |  Carr, G; Chung, MK; Mauk, AG; Andersen, RJ Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine a.J Med Chem.51:2634-7(2008)[PubMed] |
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| More Info. |
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, Solution Info
, Assay Method
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| Indoleamine 2,3-Dioxygenase |
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| Name | Indoleamine 2,3-Dioxygenase |
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| Synonyms | EC 1.13.11.52 | IDO | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type | Enzyme |
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| Mol. Mass. | 45326 |
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| Organism | Homo sapiens (human) |
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| Description | n/a |
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| Residue | 403 |
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| Sequence | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| Exiguamine A |
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| Name | Exiguamine A |
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| Synonyms: | (4S)-16'-(2-aminoethyl)-9'-hydroxy-1,3,6',6'-tetramethyl-2,5,14',20'-tetraoxo-11'-oxa-6',18'-diazaspiro[imidazolidine-4,12'-pentacyclo[11.7.0.0^{2,10}.0^{3,7}.0^{15,19}]icosane]-1'(13'),2'(10'),3'(7'),8',15'(19'),16'-hexaen-6'-ium |
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| Type | n/a |
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| Emp. Form. | C25H26N5O6 |
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| Mol. Mass. | 492.5038 |
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| SMILES | CN1C(=O)N(C)[C@@]2(Oc3c(O)cc4c(CC[N+]4(C)C)c3C3=C2C(=O)c2c(CCN)c[nH]c2C3=O)C1=O |r,c:22| |
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| Structure | |
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| L-tryptophan |
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| Name | L-tryptophan |
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| Synonyms: | (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid |
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| Type | Amino Acid |
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| Emp. Form. | C11H12N2O2 |
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| Mol. Mass. | 204.2252 |
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| SMILES | N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |
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| Structure | |
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