Reaction Details Report a problem with these data
Target
Monocarboxylate transporter 1
Ligand
BDBM22007
Substrate
BDBM21986
Meas. Tech.
Radioligand Filter Binding Assay
pH
7.8±n/a
Temperature
295.15±n/a K
Ki
6.0±n/a nM
Citation
 Guile, SD; Bantick, JR; Cheshire, DR; Cooper, ME; Davis, AM; Donald, DK; Evans, R; Eyssade, C; Ferguson, DD; Hill, S; Hutchinson, R; Ingall, AH; Kingston, LP; Martin, I; Martin, BP; Mohammed, RT; Murray, C; Perry, MW; Reynolds, RH; Thorne, PV; Wilkinson, DJ; Withnall, J Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds. Bioorg Med Chem Lett 16:2260-5 (2006) [PubMed]  Article 
Target
Name:
Monocarboxylate transporter 1
Synonyms:
MCT 1 | MCT1 | MOT1_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | Solute carrier family 16 member 1
Type:
PROTEIN
Mol. Mass.:
53956.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1451367
Residue:
500
Sequence:
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKAAESPDQKDTDGGPKEEESPV
  
Inhibitor
Name:
BDBM22007
Synonyms:
5-(cyclohexylsulfanyl)-3-methyl-1-(2-methylpropyl)-6-{[2-(trifluoromethyl)phenyl]methyl}-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione | Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 14
Type:
Small organic molecule
Emp. Form.:
C25H29F3N2O2S2
Mol. Mass.:
510.635
SMILES:
CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(SC3CCCCC3)c2c(=O)n(C)c1=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM21986
Synonyms:
5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)-1H,2H,3H,4H,6H-pyrrolo[3,4-d]pyrimidine-2,4-dione | 5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione | CHEMBL85752 | Pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione, 1 | [3H]-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione
Type:
n/a
Emp. Form.:
C25H29N3O3S
Mol. Mass.:
451.581
SMILES:
CC(C)Cn1c2cn(Cc3cccc4ccccc34)c(SCCCO)c2c(=O)n(C)c1=O
Structure:
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