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Target5-Lipoxygenase
LigandBDBM22353
Substrate/CompetitorBDBM22231
Meas. Tech.COX Inhibitor Screening Assay
IC50>10000±n/a nM
Citation Rao, PNChen, QHKnaus, EE Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases. J Med Chem49:1668-83 (2006) [PubMed]  Article
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5-Lipoxygenase
Name:5-Lipoxygenase
Synonyms:5-Lipoxygenase (5-LO)
Type:Enzyme
Mol. Mass.:97294.59
Organism:Solanum tuberosum (potato)
Description:n/a
Residue:864
Sequence:
MNIGQIMGGRELFGGHDDSKKVKGTVVMMKKNALDFTDLAGSLTDIAFDVLGQKVSFQLI
SSVQGDPTNGLQGKHSNPAYLENSLFTLTPLTAGSETAFGVTFDWNEEFGVPGAFIIKNT
HINEFFLKSLTLEDVPNHGKVHFDCNSWVYPSFRYKSDRIFFANQPYLPSKTPELLRKYR
ENELLTLRGDGTGKREAWDRIYDYDIYNDLGNPDQGKENVRTTLGGSAEYPYPRRGRTGR
PPTRTDPKSESRIPLLLSLDIYVPRDERFGHLKMSDFLTYALKSIVQFILPELHALFDGT
PNEFDSFEDVLRLYEGGIKLPQGPLFKALTAAIPLEMIKELLRTDGEGILRFPTPLVIKD
SKTAWRTDEEFAREMLAGVNPIIISRLQEFPPKSKLDPEAYGNQNSTITAEHIEDKLDGL
TVDEAMNNNKLFILNHHDLLIPYLRRINTTITKSYASRTLLFLQDNGSLKPLAIELSLPH
PDGDQFGVTSKVYTPSDQGVESSIWQLAKAYVAVNDAGVHQLISHWLNTHAVIEPFVIAT
NRQLSVLHPIHKLLYPHFRDTMNINASARQILINAGGVLESTVFQSKFALEMSAVVYKDW
VFPDQALPADLVKRGVAVEDSSSPHGVRLLIEDYPYAVDGLEIWSAIKSWVTDYCSFYYG
SDEEILKDNELQAWWKELREVGHGDKKNEPWWPEMETPQELIDSCTTIIWIASALHAAVN
FGQYPYAGYLPNRPTVSRRFMPEPGTPEYEELKKNPDKAFLKTITAQLQTLLGVSLVEIL
SRHTTDEIYLGQRESPEWTKDKEPLAAFDKFGKKLTDIEKQIIQRNGDNILTNRSGPVNA
PYTLLFPTSEGGLTGKGIPNSVSI
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BDBM22353
NameBDBM22353
Synonyms:1,3-Diarylprop-2-yn-1-one, 13j | 3-(4-methanesulfonylphenyl)-1-(4-methoxyphenyl)prop-2-yn-1-one | CHEMBL371191
TypeSmall organic molecule
Emp. Form.C17H14O4S
Mol. Mass.314.356
SMILESCOc1ccc(cc1)C(=O)C#Cc1ccc(cc1)S(C)(=O)=O
Structure
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BDBM22231
NameBDBM22231
Synonyms:(9Z,12Z)-octadeca-9,12-dienoic acid | CHEMBL267476 | Linoleic Acid | Linoleic acid (LA)
TypeUnsaturated fatty acid
Emp. Form.C18H32O2
Mol. Mass.280.4455
SMILESCCCCC\C=C/C\C=C/CCCCCCCC(O)=O
Structure
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