Reaction Details Report a problem with these data
Target
Estrogen-related receptor gamma
Ligand
BDBM22438
Substrate
Biotinylated RIP140 peptide
Meas. Tech.
ERRgamma FRET Assay
pH
7±n/a
Temperature
295.15±n/a K
EC50
1300±n/a nM
Citation
 Zuercher, WJ; Gaillard, S; Orband-Miller, LA; Chao, EY; Shearer, BG; Jones, DG; Miller, AB; Collins, JL; McDonnell, DP; Willson, TM Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J Med Chem 48:3107-9 (2005) [PubMed]  Article 
Target
Name:
Estrogen-related receptor gamma
Synonyms:
ERR gamma-2 | ERR3 | ERR3_HUMAN | ERRG2 | ESRRG | Estrogen receptor-related protein 3 | Estrogen-Related Receptor, gamma | Estrogen-related receptor gamma | KIAA0832 | NR3B3 | Nuclear receptor subfamily 3 group B member 3
Type:
PROTEIN
Mol. Mass.:
51305.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1501351
Residue:
458
Sequence:
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
  
Inhibitor
Name:
BDBM22438
Synonyms:
4-Hydroxy-benzoic acid (4-isopropyl-benzylidene)-hydrazide | 4-hydroxy-N'-[(1E)-[4-(propan-2-yl)phenyl]methylidene]benzohydrazide | GSK 4716 | GSK4716
Type:
Small organic molecule
Emp. Form.:
C17H18N2O2
Mol. Mass.:
282.337
SMILES:
CC(C)c1ccc(\C=N\NC(=O)c2ccc(O)cc2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Biotinylated RIP140 peptide (aa 366-390)
Synonyms:
NRIP1 | NRIP1_HUMAN | Nuclear factor RIP140, 366-390 | Receptor-interacting protein 140 derived peptide
Type:
Peptide
Mol. Mass.:
2831.78
Organism:
Homo sapiens (Human)
Description:
P48552[366-390]
Residue:
25
Sequence:
LERNNIKQAANNSLLLHLLKSQTIP