Reaction Details Report a problem with these data
Target
Estrogen-related receptor gamma
Ligand
BDBM22442
Substrate
Biotinylated RIP140 peptide
Meas. Tech.
ERRgamma FRET Assay
pH
7±n/a
Temperature
295.15±n/a K
EC50
1600±n/a nM
Citation
 Zuercher, WJ; Gaillard, S; Orband-Miller, LA; Chao, EY; Shearer, BG; Jones, DG; Miller, AB; Collins, JL; McDonnell, DP; Willson, TM Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J Med Chem 48:3107-9 (2005) [PubMed]  Article 
Target
Name:
Estrogen-related receptor gamma
Synonyms:
ERR gamma-2 | ERR3 | ERR3_HUMAN | ERRG2 | ESRRG | Estrogen receptor-related protein 3 | Estrogen-Related Receptor, gamma | Estrogen-related receptor gamma | KIAA0832 | NR3B3 | Nuclear receptor subfamily 3 group B member 3
Type:
PROTEIN
Mol. Mass.:
51305.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1501351
Residue:
458
Sequence:
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
  
Inhibitor
Name:
BDBM22442
Synonyms:
Acyl Hydrazone, 7 | N'-[(1E)-[4-(diethylamino)phenyl]methylidene]benzohydrazide
Type:
Small organic molecule
Emp. Form.:
C18H21N3O
Mol. Mass.:
295.3788
SMILES:
CCN(CC)c1ccc(\C=N\NC(=O)c2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Biotinylated RIP140 peptide (aa 366-390)
Synonyms:
NRIP1 | NRIP1_HUMAN | Nuclear factor RIP140, 366-390 | Receptor-interacting protein 140 derived peptide
Type:
Peptide
Mol. Mass.:
2831.78
Organism:
Homo sapiens (Human)
Description:
P48552[366-390]
Residue:
25
Sequence:
LERNNIKQAANNSLLLHLLKSQTIP