Reaction Details Report a problem with these data
Target
Malate dehydrogenase, cytoplasmic
Ligand
BDBM23224
Substrate
BDBM23230
Meas. Tech.
Lactate Dehydrogenase Inhibition Assay
IC50
>232000±n/a nM
Citation
Choi, SR; Pradhan, A; Hammond, NL; Chittiboyina, AG; Tekwani, BL; Avery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem 50:3841-50 (2007) [PubMed] Article
More Info.:
Target
Name:
Malate dehydrogenase, cytoplasmic
Synonyms:
Cytosolic malate dehydrogenase | MDH1 | MDHC_PIG | Malate Dehydrogenase, cytoplasmic | Malate dehydrogenase cytoplasmic
Type:
Oxidoreductase; homodimer
Mol. Mass.:
36453.77
Organism:
Sus scrofa (pig)
Description:
Porcine heart cytoplasmic fraction.
Residue:
334
Sequence:
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEEIAFKDLDVAILVGSMPRRDGMERKDLLKANVKIFKCQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTSDDVKNVIIWGNHSSTQYPDVNHAKVKLQAKEVGVYEAVKDDSWLKGEFITTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGIISDGNSYGVPDDLLYSFPVTIKDKTWKIVEGLPINDFSREKMDLTAKELAEEKETAFEFLSSA
Inhibitor
Name:
BDBM23224
Synonyms:
7-{[4-(formamidoformic acid)-3-methoxyphenyl]methoxy}-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | Oxamic acid derivative, 1
Type:
Small organic molecule
Emp. Form.:
C20H15NO10
Mol. Mass.:
429.3338
SMILES:
COc1cc(COc2cc(O)c3c(c2)oc(cc3=O)C(O)=O)ccc1NC(=O)C(O)=O