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TargetMatrix Metalloproteinase-14 (MMP-14)
Ligandbeta-sulfonyl hydroxamate analogue, 7
Substrate/CompetitorWammp-5
Meas. Tech.MMP Inhibition Assay
pH7.4±n/a
Temperature295.15±n/a K
IC50 2370±300 nM
Citation Huang, A; Joseph-McCarthy, D; Lovering, F; Sun, L; Wang, W; Xu, W; Zhu, Y; Cui, J; Zhang, Y; Levin, JI Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.Bioorg Med Chem.15:6170-81(2007)[PubMed]
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Matrix Metalloproteinase-14 (MMP-14)
NameMatrix Metalloproteinase-14 (MMP-14)
SynonymsEC 3.4.24.80 | MT-MMP 1 | MTMMP1| MT1-MMP | MT1MMP | MMP-X1 | Membrane-type matrix metalloproteinase 1 | Membrane-type-1 matrix metalloproteinase
TypeSingle-pass type I membrane protein;metalloprotease
Mol. Mass.n/a
OrganismHomo sapiens (human)
DescriptionThe recombinant catalytic domain was used in the assay.
Residue177
Sequence
IQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEK
QADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDI
FLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFP
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beta-sulfonyl hydroxamate analogue, 7
Namebeta-sulfonyl hydroxamate analogue, 7
Synonyms:tert-butyl 4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
TypeSmall organic molecule
Emp. Form.C22H31N3O6S
Mol. Mass.465.563
SMILESCC#CCNc1ccc(cc1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC(C)(C)C)C(=O)NO
Structure
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Wammp-5
NameWammp-5
Synonyms:7-methoxycoumarin-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH
TypeFluorogenic substrate
Emp. Form.n/a
Mol. Mass.n/a
SMILESn/a
Structure