Target
Neutrophil elastase
Ligand
BDBM23711
Substrate
BDBM23699
Meas. Tech.
Human Neutrophil Elastase Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
46±n/a nM
Citation
 Schepetkin, IAKhlebnikov, AIQuinn, MT N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem 50:4928-38 (2007) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM23711
Synonyms:
1-benzoyl-3-nitro-1H-pyrazole | N-Benzoylpyrazole deriv., 19
Type:
Small organic molecule
Emp. Form.:
C10H7N3O3
Mol. Mass.:
217.1809
SMILES:
[O-][N+](=O)c1ccn(n1)C(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23699
Synonyms:
N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin
Type:
Chromogenic substrate
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: