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Reaction Details
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TargetMatriptase
LigandBDBM23877
Substrate/CompetitorBDBM23868
Meas. Tech.Determination of Inhibition Constants
pH8±n/a
Temperature298.15±n/a K
Ki 44±n/a nM
Citation Steinmetzer, TSchweinitz, AStürzebecher, ADönnecke, DUhland, KSchuster, OSteinmetzer, PMüller, FFriedrich, RThan, MEBode, WStürzebecher, J Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase. J Med Chem49:4116-26 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Matriptase
Name:Hepatocyte growth factor activator/Serine protease hepsin/Suppressor of tumorigenicity 14 protein
Synonyms:Epithin | MT-SP1 | Membrane-type serine protease 1 | Prostamin | ST14 | Serine protease TADG-15 | Suppressor of tumorigenicity 14 protein | Suppressor of tumorigenicity protein 14
Type:Single-pass type II membrane protein
Mol. Mass.:94769.23
Organism:Homo sapiens (Human)
Description:n/a
Residue:855
Sequence:
MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
RLPLFRDWIKENTGV
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  Blast E-value cutoff:
BDBM23877
NameBDBM23877
Synonyms:3-[(2S)-2-(anthracene-2-sulfonamido)-3-[4-(3-carbamimidamidopropanoyl)piperazin-1-yl]-3-oxopropyl]benzene-1-carboximidamide | 3-amidinophenylalanine deriv., 21
TypeSmall organic molecule
Emp. Form.C32H36N8O4S
Mol. Mass.628.744
SMILES[#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6](=O)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#6@H](-[#6]-c1cccc(c1)-[#6](-[#7])=[#7])-[#7]S(=O)(=O)c1ccc2cc3ccccc3cc2c1 |r|
Structure
BDBM23868
NameBDBM23868
Synonyms:(2S)-5-carbamimidamido-2-{2-[(2R)-3-(4-hydroxycyclohexyl)-2-methanesulfonamidopropanamido]acetamido}-N-(4-nitrophenyl)pentanamide | N-Methylsulfonyl-D-hexahydrotyrosyl-glycyl-L-arginine-4-nitroanilide | Pefachrome tPA
Typechromogenic substrate
Emp. Form.C24H38N8O8S
Mol. Mass.598.672
SMILESCS(=O)(=O)NC(CC1CCC(O)CC1)C(=O)NCC(=O)NC(CCC\[NH+]=C(/N)[NH-])C(=O)Nc1ccc(cc1)[N+]([O-])=O |(26.51,-19.37,;25.18,-18.6,;24.41,-19.93,;25.95,-17.27,;23.84,-17.83,;22.51,-18.6,;21.18,-17.83,;21.18,-16.29,;22.51,-15.52,;22.51,-13.98,;21.18,-13.21,;21.18,-11.67,;19.84,-13.98,;19.84,-15.52,;22.51,-20.14,;23.84,-20.91,;21.18,-20.91,;21.18,-22.45,;19.84,-23.22,;18.51,-22.45,;19.84,-24.76,;18.51,-25.53,;17.18,-24.76,;17.18,-23.22,;15.84,-22.45,;15.84,-20.91,;14.51,-20.14,;13.17,-20.91,;14.51,-18.6,;18.51,-27.07,;19.84,-27.84,;17.18,-27.84,;17.18,-29.38,;18.51,-30.15,;18.51,-31.69,;17.18,-32.46,;15.84,-31.69,;15.84,-30.15,;17.18,-34,;15.84,-34.77,;18.51,-34.77,)|
Structure