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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM377163
Substrate
n/a
Meas. Tech.
Pim Enzyme Assays
IC50
550±n/a nM
Citation
 Xue, C; Feng, H; Li, Y; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors US Patent  US10265307 Publication Date 4/23/2019 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM377163
Synonyms:
5-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-cyano-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide | US10265307, Example 18-1 | US10517858, Example 18 (Diastereoisomer 1) | US10828290, Example 18 (Diastereoisomer 1) | US11229631, Example 18 Diastereoisomer 1
Type:
Small organic molecule
Emp. Form.:
C24H23F2N7OS
Mol. Mass.:
495.548
SMILES:
N[C@H]1CCCN(C1)c1c2CC[C@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F |r|
Structure:
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